Cryptococcosis Presenting as a Colonic Ulcer in a Kidney Transplant Recipient: A Case Report.

Abstract

We present a case of a 59-year-old woman with Chagas disease who received a kidney transplant. At month 44 post-transplantation, the patient presented with diarrhea that had persisted for 2 months. Colonoscopy showed a colon ulcer and differential diagnoses included cytomegalovirus, bacteria, or parasite infection; drug-related diarrhea; Crohn's disease; celiac disease; and malignancy. The ulcer tissue was positive for Cryptococcus neoformans. Successful treatment consisted of amphotericin B for 8 days and oral fluconazole (800 mg daily) for 3 months. This case illustrates that a colonic ulcer, although rare, could be cryptococcosis.

• Authors: F Cicora, J Petroni, J Roberti
• Journal: Transplantation proceedings (Transplant Proc) Vol. 47 Issue 9 Pg. 2786-7 (Nov 2015) ISSN: 1873-2623 [Electronic] United States
• PMID: 26680095 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Antifungal Agents
• Amphotericin B
• Fluconazole

Topics

• Amphotericin B (administration & dosage)
• Antifungal Agents (administration & dosage)
• Colonic Diseases (diagnosis, microbiology)
• Cryptococcosis (microbiology)
• Cryptococcus neoformans
• Diagnosis, Differential
• Female
• Fluconazole (administration & dosage)
• Humans
• Kidney Transplantation (adverse effects)
• Middle Aged
• Ulcer (diagnosis, microbiology)