Is There a Role for Desmopressin in Liver Transplantation? A Case Report.

Abstract

Living donor liver transplantation reduces time and mortality on the waiting list. Bleeding is a serious complication; however, "overcorrection" of coagulopathy may lead to hepatic artery thrombosis. We report a case where desmopressin (DDAVP) was used in the management of persistent postreperfusion bleeding (44 red blood cell units transfused). After 1 dose of DDAVP, bleeding improved significantly and the recipient had an unremarkable recovery. DDAVP should be considered for persisting bleeding after correcting common coagulation abnormalities where complexity of the anastomosis may preclude the use of more aggressive procoagulant drugs in liver transplantation.

• Authors: M M Gonzales, D Z Valdes, R Helmick, T Taner, G Vasdev
• Journal: Transplantation proceedings (Transplant Proc) Vol. 47 Issue 9 Pg. 2782-5 (Nov 2015) ISSN: 1873-2623 [Electronic] United States
• PMID: 26680094 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Hemostatics
• Deamino Arginine Vasopressin

Topics

• Deamino Arginine Vasopressin (therapeutic use)
• Hemostatics (therapeutic use)
• Humans
• Liver (blood supply, drug effects)
• Liver Transplantation (adverse effects, methods)
• Male
• Middle Aged
• Postoperative Hemorrhage (drug therapy, etiology)
• Reperfusion Injury (drug therapy, etiology)