HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Immunological models in high dilution research following M Bastide.

Abstract
In 1994, Madeleine Bastide described experimental models in immunology that were used during the 1980s to investigate high dilution effects on several biological systems. She classified the available papers in four categories: High dilutions of antigens; High dilutions of thymus, bursa and other hormones; High dilutions of cytokines; Immunopharmacological activity of silica. The studies about high dilutions of antigens were not continued after this period, but gave rise to a long process of a series of in vitro models on antigens and histamine dilutions, that led to the demonstration of the biological modulation effects of these preparations on basophil degranulation. During this process, a multi-centre study was performed, with a high degree of reproducibility among different independent laboratories. The studies about high diluted cytokines, thymulin and other hormones opened a new line of scientific investigation, about the regulatory properties of endogenous substances prepared according to homeopathic methods. The most frequently studied substance, thymulin, when administered to mice at 5cH potency, is able to improve the activity of phagocytes in different experimental situations, such as viral, bacterial and parasitic infections. The immunopharmacological activity of silica was demonstrated, at that time, as an in vivo illustration of the homeopathic 'similia principle'. More recently, studies on silica have assumed another focus: the putative role of silica as active contaminant present in high dilutions. This paper presents a follow-up summary on these items, considering the evolution of discoveries from 1994 to 2014.
AuthorsLeoni Villano Bonamin, Paolo Bellavite
JournalHomeopathy : the journal of the Faculty of Homeopathy (Homeopathy) Vol. 104 Issue 4 Pg. 263-8 (Oct 2015) ISSN: 1476-4245 [Electronic] Germany
PMID26678727 (Publication Type: Journal Article)
CopyrightCopyright © 2015 The Faculty of Homeopathy. Published by Elsevier Ltd. All rights reserved.
Topics
  • Animals
  • Homeopathy (methods)
  • Indicator Dilution Techniques (statistics & numerical data)
  • Mice (blood, growth & development)
  • Models, Immunological
  • Reproducibility of Results
  • Research (standards)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: