Coexistence of the 677C>T and 1298A>C MTHFR polymorphisms and its significance in the population of Polish women.

Abstract

OBJECTIVES:

The aim of the study was to evaluate the frequency of the 677C>T and 1298A>C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene, as well as the coexistence of both these genetic variants in women from the Polish population.

MATERIAL AND METHODS:

A total of 662 women from the Polish population were enrolled in the study group. The frequency of the investigated genotypes of the 677C>T and 1298A>C polymorphisms of the MTHFR gene was analyzed with the use of PCR/RFLP methods.

RESULTS:

The frequency of the 677CC, 677CT and 677TT genotypes in the studied population of women was 50.60%, 39.88% and 9.52%, respectively As to the 1298AA, 1298AC and 1298CC genotypes, the obtained results were as follows: 42.75%, 47.88% and 9.37%, respectively (Tables II and III). Simultaneous analysis revealed the most frequent coexistence of 677CC/1298AC (28.85%), 677CT/1298AA (20.85%) and 677CT/1298AC (19.03%) genotypes. The coexistence of 677CC/1298AA (12.39%), 677CC/1298CC (9.37%) and 677TT/1298AA (9.51%) genotypes was observed less frequently In the studied population of Polish women, the coexistence of 677CT/1298CC, 677TT/1298AC and 677TT/1298CC genotypes has been not observed.

CONCLUSIONS:

The frequency and coexistence of genotypes of the 677C>T and 1298A>C MTHFR gene polymorphisms in the studied population of Polish women is similar to other North-European populations. Women carriers of the mutated variants of both, 677C>T and 1298A>C polymorphisms of the MTHFR gene should receive special perinatal care in order to prevent fetal defects and thrombosis-related complications during pregnancy It is vital to emphasize the significance of proper education of folate supplementation, especially in pregnant patients and women of reproductive age.

• Authors: Hubert Wolski, Maria Kocięcka, Aleksandra E Mrozikiewicz, Magdalena Barlik, Grażyna Kurzawińska
• Journal: Ginekologia polska (Ginekol Pol) Vol. 86 Issue 10 Pg. 742-7 (Oct 2015) ISSN: 0017-0011 [Print] Poland
• PMID: 26677583 (Publication Type: Journal Article)

Chemical References

• Folic Acid
• Methylenetetrahydrofolate Reductase (NADPH2)

Topics

• Female
• Folic Acid (administration & dosage)
• Genetic Predisposition to Disease
• Humans
• Methylenetetrahydrofolate Reductase (NADPH2) (genetics)
• Perinatal Care (methods)
• Poland
• Polymorphism, Genetic
• Polymorphism, Restriction Fragment Length (genetics)
• Pregnancy
• Pregnancy Complications (prevention & control)
• White People (genetics)