Commentary on Inhaled (239)PUO2 in Dogs - A Prophylaxis Against Lung Cancer?

Abstract

Several studies on the effect of inhaled plutonium-dioxide particulates and the incidence of lung tumors in dogs reveal beneficial effects when the cumulative alpha-radiation dose is low. There is a threshold at an exposure level of about 100 cGy for excess tumor incidence and reduced lifespan. The observations conform to the expectations of the radiation hormesis dose-response model and contradict the predictions of the LNT hypothesis. These studies suggest investigating the possibility of employing low-dose alpha-radiation, such as from (239)PuO2 inhalation, as a prophylaxis against lung cancer.

• Authors: Jerry M Cuttler, Ludwig E Feinendegen
• Journal: Dose-response : a publication of International Hormesis Society (Dose Response) 2015 Jan-Mar Vol. 13 Issue 1 ISSN: 1559-3258 [Print] United States
• PMID: 26675366 (Publication Type: Journal Article)