Screening of Peroxisome Proliferator-Activated Receptors (PPARs) α, γ and α Gene Polymorphisms for Obesity and Metabolic Syndrome Association in the Multi-Ethnic Malaysian Population.

Abstract

OBJECTIVE:

This study aimed to investigate the association of peroxisome proliferator-activated receptor (PPAR) genes PPARα L162V, PPARγ2 C161T and PPARδ T294C single nucleotide polymorphisms (SNPs) with obesity and metabolic syndrome (Met-S) in a multi-ethnic population in Kampar, Malaysia.

METHODS:

Socio-demographic data, anthropometric and biochemical measurements (plasma lipid profile, adiponectin and interleukin-6 [IL-6] levels) were taken from 307 participants (124 males; 180 obese; 249 Met-S; 97 Malays, 85 ethnic Chinese, 55 ethnic Indians).

RESULTS:

The overall minor allele frequencies were .08, .22 and .30 for PPAR α L162V, γ C161T, δ T294C, respectively. All SNPs were not associated with obesity, Met-S and obesity with/without Met-S by χ(2) analysis, ethnicity-stratified and logistic regression analyses. Nevertheless, participants with V162 allele of PPARα had significantly higher IL-6, while those with T161 allele of PPARγ2 had significantly lower HOMA-IR.

CONCLUSIONS:

All PPAR SNPs were not associated with obesity and Met-S in the suburban population of Kampar, Malaysia, where only PPARα V162 and PPARγ2 T161 alleles were associated with plasma IL-6 and HOMA-IR, respectively.

• Authors: Phee-Phee Chia, Sook-Ha Fan, Yee-How Say
• Journal: Ethnicity & disease (Ethn Dis) Vol. 25 Issue 4 Pg. 383-90 (Nov 05 2015) ISSN: 1049-510X [Print] United States
• PMID: 26673968 (Publication Type: Journal Article)

Chemical References

• ADIPOQ protein, human
• Adiponectin
• IL6 protein, human
• Interleukin-6
• Peroxisome Proliferator-Activated Receptors

Topics

• Adiponectin (blood)
• Adult
• Aged
• Aged, 80 and over
• Anthropometry
• Asian People (genetics)
• Ethnicity (genetics)
• Female
• Gene Frequency
• Humans
• Interleukin-6 (blood)
• Malaysia
• Male
• Metabolic Syndrome (blood, ethnology, genetics)
• Middle Aged
• Obesity (blood, ethnology, genetics)
• Peroxisome Proliferator-Activated Receptors (genetics)
• Polymorphism, Single Nucleotide (genetics)
• Young Adult