Nonhormonal mediation of male reproductive tract damage: data from contraceptive drug research.

Abstract

Chemicals can interfere with hormonal control of the male reproductive tract and/or directly alter male reproductive tract function. A review is presented of those chemicals developed and tested as male contraceptive agents which have a direct effect on the male reproductive tract with minimal disturbance of the hormonal milieu. Such chemicals can have one or more sites of action: 1) the testis, disturbing spermatogenesis; 2) the epididymis, altering sperm maturation; 3) the vas deferens, affecting sperm transport; and 4) the accessory sex glands, entering the ejaculate and changing the functional activity of the spermatozoa. Examples of each mode of action are presented.

• Authors: L J Zaneveld, D P Waller
• Journal: Progress in clinical and biological research (Prog Clin Biol Res) Vol. 302 Pg. 129-49; discussion 150-6 ( 1989) ISSN: 0361-7742 [Print] United States
• PMID: 2666986 (Publication Type: Journal Article, Review)

Chemical References

• Contraceptive Agents, Male

Topics

• Animals
• Contraceptive Agents, Male (pharmacology)
• Epididymis (drug effects, physiology)
• Genitalia, Male (drug effects, physiology)
• Male
• Testis (drug effects, physiology)
• Vas Deferens (drug effects, physiology)