Abstract | OBJECTIVE: METHODS: Sixty male SD rats were randomly divided into six groups: blank control, model, 15 min- moxibustion (15 min-moxi), 30 min-moxi, 60 min-moxi and 90 min-moxi (n = 10 rats in each group). The asthma model was established by intraperitoneal injection of suspension of egg protein, magaldrate, and inactivated Bacillus pertussis (on day 1 and 8), and inhaling the atomized ovalbumin saline (from day 15 on for 14 days). Mild moxibustion was conducted at "Dazhui" (GV 14) for 15 min, 30 min, 60 min and 90 min, respectively, once daily for 7 days. The levels of NGF, SP, CGRP, NKA, NKB, and pERK in the BALF were detected by ELISA ( enzyme-linked immuno sorbent assay). RESULTS: The contents of NGF, SP, CGRP, NKA, NKB and pERK in the BALF in the model group were obviously higher than those in the blank control group (P < 0.01), suggesting an apparent inflammatory reaction in rats after modeling. Following moxibustion, the levels of NGF, SP, CGRP, NKA, NKB and pERK of the four treatment groups were significantly down-regulated compared with the model group (P < 0.01). The effect of 30 min-moxi group was obviously superior to that of 15 min-moxi group (P < 0.01), and those of 60 min-moxi and 90 min-moxi groups were markedly superior to those of 15 min-moxi and 30 min-moxi groups (P < 0.01) in down-regulating NGF, SP, CGRP, NKA, NKB, and pERK levels in the BALF. No significant differences were found between the 60 min-moxi and 90 min-moxi groups in down-regulating NGF, SP, CGRP, NKA, NKB, and pERK levels (P > 0.05). CONCLUSION:
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Authors | Wei Zhang, Lin Jiao, Jun Xiong |
Journal | Zhen ci yan jiu = Acupuncture research
(Zhen Ci Yan Jiu)
Vol. 40
Issue 5
Pg. 388-91
(Oct 2015)
ISSN: 1000-0607 [Print] China |
PMID | 26669196
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Substance P
- Neurokinin A
- Nerve Growth Factor
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Topics |
- Acupuncture Points
- Animals
- Asthma
(metabolism, therapy)
- Bronchoalveolar Lavage Fluid
(chemistry)
- Humans
- Male
- Moxibustion
(methods)
- Nerve Growth Factor
(analysis, metabolism)
- Neurogenic Inflammation
(metabolism, therapy)
- Neurokinin A
(analysis, metabolism)
- Rats
- Rats, Sprague-Dawley
- Substance P
(analysis, metabolism)
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