Anti-diabetic Effect of Friedelan Triterpenoids in Streptozotocin Induced Diabetic Rat.

Abstract

We herein report the anti-diabetic effect of the natural friedelan tritepenoid, 4-oxa-3, 4-secofriedelan (cerin), isolated from cork tissue of Quercus suber L. and its oxygenated derivative, 4-oxa-3, 4-secofriedelan-3-oic acid (cerin(ox)) in streptozotocin (STZ)-induced diabetic rat. Male Sprague Dawley rats were randomized into four groups: non-diabetic control (Group I), STZ-induced diabetic rats (Group II), STZ-induced diabetic rats treated with cerin (Group III), and STZ-induced diabetic rats treated with cerin(ox), (Group IV). Administration of cerin (3 mg/kg) and cerin(ox), (3 mg/kg) orally to STZ-diabetic rats for three weeks improved the body weight, reduced serum glucose level and activities of alkaline phosphatase, acid phosphatase, glutamate-oxaloacetate transaminase and glutamate-pyruvate transaminase, and restored liver antioxidant status.

• Authors: Amitava Mandal, Vaskar Das, Pranab Ghosh, Shilpi Ghosh
• Journal: Natural product communications (Nat Prod Commun) Vol. 10 Issue 10 Pg. 1683-6 (Oct 2015) ISSN: 1934-578X [Print] United States
• PMID: 26669102 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2-hydroxyfriedelan-3-one
• Blood Glucose
• Hypoglycemic Agents
• Triterpenes

Topics

• Animals
• Blood Glucose
• Diabetes Mellitus, Experimental (drug therapy)
• Hypoglycemic Agents (chemistry, therapeutic use)
• Male
• Quercus (chemistry)
• Rats
• Rats, Sprague-Dawley
• Triterpenes (chemistry, therapeutic use)