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[Photothermal effects of metallic carbon nanotubes on human breast cancer cells].

Abstract
SWNTs are a mixture of 1/3 metallic SWNTs (m-SWNTs) and 2/3 semiconducting SWNTs (s-SWNTs). It is desirable to separate the metallic SWNTs from the semi-conducting ones. In this study m-SWNTs was separated by using a poly[(m-phenylenevinylene)-alt-(p-phenylenevinylene)] (PmPV) derivative and used as photo-thermal media instead of SWNTs. The separation effects of m-SWNTs were evaluated by Raman spectra, molecular modeling and TEM images. The effects of m-SWNTs on MCF-7 cell proliferation and apoptosis were evaluated with MTT assay and flow cytometry, respectively. m-SWNTs were separated with high purity. A strong inhibition of MCF-7 cell growth was observed with the m-SWNTs under near-infrared (NIR) light irradiation. Our results will be helpful for the potential applications of m-SWNTs in clinical photothermal cancer therapy.
AuthorsJin Hou, Man Mi, Ming Wei, Wen-hui Yi
JournalYao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 50 Issue 8 Pg. 980-5 (Aug 2015) ISSN: 0513-4870 [Print] China
PMID26668997 (Publication Type: Journal Article)
Chemical References
  • Nanotubes, Carbon
Topics
  • Apoptosis
  • Breast Neoplasms (pathology)
  • Flow Cytometry
  • Humans
  • Light
  • MCF-7 Cells (drug effects)
  • Models, Molecular
  • Nanotubes, Carbon

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