Abstract |
SWNTs are a mixture of 1/3 metallic SWNTs (m-SWNTs) and 2/3 semiconducting SWNTs (s-SWNTs). It is desirable to separate the metallic SWNTs from the semi-conducting ones. In this study m-SWNTs was separated by using a poly[(m-phenylenevinylene)-alt-(p-phenylenevinylene)] (PmPV) derivative and used as photo-thermal media instead of SWNTs. The separation effects of m-SWNTs were evaluated by Raman spectra, molecular modeling and TEM images. The effects of m-SWNTs on MCF-7 cell proliferation and apoptosis were evaluated with MTT assay and flow cytometry, respectively. m-SWNTs were separated with high purity. A strong inhibition of MCF-7 cell growth was observed with the m-SWNTs under near-infrared (NIR) light irradiation. Our results will be helpful for the potential applications of m-SWNTs in clinical photothermal cancer therapy.
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Authors | Jin Hou, Man Mi, Ming Wei, Wen-hui Yi |
Journal | Yao xue xue bao = Acta pharmaceutica Sinica
(Yao Xue Xue Bao)
Vol. 50
Issue 8
Pg. 980-5
(Aug 2015)
ISSN: 0513-4870 [Print] China |
PMID | 26668997
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Apoptosis
- Breast Neoplasms
(pathology)
- Flow Cytometry
- Humans
- Light
- MCF-7 Cells
(drug effects)
- Models, Molecular
- Nanotubes, Carbon
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