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Curcumin half analog modulates interleukin-6 and tumor necrosis factor-alpha in inflammatory bowel disease.

AbstractBACKGROUND:
The present study was aimed at examining the effect of dehydrozingerone (DHZ), half analogue of curcumin which is the active constituent of turmeric (Curcuma longa) in the di-nitrochlorobenzene (DNCB) induced model for inflammatory bowel disease (IBD).
MATERIALS AND METHODS:
Male Wistar rats (200-220 g) were divided into four groups (n = 6). Chemical induction of IBD was done by sensitizing with 300 µL of 20 g/L of DNCB (in acetone) onto the nape of rats for 14 days followed by intra-colonic instillation of 250 µL of DNCB (0.1% DNCB in 50% alcohol) solution on day 15. Rats in Group 1 (normal control) and Group 2 (DNCB control) were treated with vehicle. Rats in Group 3 were treated with DHZ (100 mg/kg, p.o.; 8 days) and Group 4 animals were treated with sulfasalazine (SS) (100 mg/kg, p.o.; 8 days). On 24(th) day, the rats were killed, colon removed and the macroscopic, biochemical, and histopathological evaluations were performed.
RESULTS:
The levels of myeloperoxidase, thiobarbituric acid reactive substrate, and nitrite increased significantly (P < 0.05) in the DNCB group whereas reduced significantly in the DHZ and SS treated groups. Serum nitrite levels were found to be insignificant between the different groups. Interleukin-6, tumor necrosis factor-alpha level was significantly high in the DNCB group.
CONCLUSION:
These findings show that DHZ can be a promising molecule for the treatment of IBD.
AuthorsPhani Krishna Kondamudi, Hemalatha Kovelamudi, Pawan G Nayak, Mallikarjuna Chamallamudi Rao, Rekha Raghuveer Shenoy
JournalPharmacognosy magazine (Pharmacogn Mag) Vol. 11 Issue Suppl 2 Pg. S296-302 (Oct 2015) ISSN: 0973-1296 [Print] India
PMID26664018 (Publication Type: Journal Article)

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