Abstract | BACKGROUND: MATERIALS AND METHODS: Male Wistar rats (200-220 g) were divided into four groups (n = 6). Chemical induction of IBD was done by sensitizing with 300 µL of 20 g/L of DNCB (in acetone) onto the nape of rats for 14 days followed by intra-colonic instillation of 250 µL of DNCB (0.1% DNCB in 50% alcohol) solution on day 15. Rats in Group 1 (normal control) and Group 2 ( DNCB control) were treated with vehicle. Rats in Group 3 were treated with DHZ (100 mg/kg, p.o.; 8 days) and Group 4 animals were treated with sulfasalazine (SS) (100 mg/kg, p.o.; 8 days). On 24(th) day, the rats were killed, colon removed and the macroscopic, biochemical, and histopathological evaluations were performed. RESULTS: CONCLUSION: These findings show that DHZ can be a promising molecule for the treatment of IBD.
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Authors | Phani Krishna Kondamudi, Hemalatha Kovelamudi, Pawan G Nayak, Mallikarjuna Chamallamudi Rao, Rekha Raghuveer Shenoy |
Journal | Pharmacognosy magazine
(Pharmacogn Mag)
Vol. 11
Issue Suppl 2
Pg. S296-302
(Oct 2015)
ISSN: 0973-1296 [Print] India |
PMID | 26664018
(Publication Type: Journal Article)
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