Abstract |
Two antitussives, dextromethorphan and carbetapentane, which have been reported to bind to a common binding site in brain tissue and produce anticonvulsant effects in rats, were evaluated for their anticonvulsant effects against maximal electroshock-induced seizures, for their neurological impairing effects on the horizontal screen test, and their protective effects against N-methyl-D-aspartic acid ( NMDA)-induced lethality in mice. Both compounds protected animals against maximal electroshock-induced seizures in a dose-related fashion after either intraperitoneal or oral administration. The neurologically impairing doses were approximately 1.5 times the anticonvulsant doses. As a function of dose, dextromethorphan, but not carbetapentane, protected mice from NMDA-induced lethality. Since carbetapentane had an anticonvulsant action without protecting against NMDA-induced lethality, these data support the hypothesis that dextromethorphan and carbetapentane may have a common anticonvulsant action separate from the phencyclidine-like, NMDA-antagonist action which only dextromethorphan exhibits.
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Authors | J D Leander |
Journal | Epilepsy research
(Epilepsy Res)
1989 Jul-Aug
Vol. 4
Issue 1
Pg. 28-33
ISSN: 0920-1211 [Print] Netherlands |
PMID | 2666123
(Publication Type: Journal Article)
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Chemical References |
- Anticonvulsants
- Antitussive Agents
- Cyclopentanes
- Levorphanol
- Aspartic Acid
- carbetapentane
- N-Methylaspartate
- Dextromethorphan
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Topics |
- Animals
- Anticonvulsants
(therapeutic use)
- Antitussive Agents
(therapeutic use)
- Aspartic Acid
(analogs & derivatives, antagonists & inhibitors, toxicity)
- Cyclopentanes
(therapeutic use)
- Dextromethorphan
(therapeutic use)
- Dose-Response Relationship, Drug
- Levorphanol
(analogs & derivatives)
- Male
- Mice
- N-Methylaspartate
- Seizures
(chemically induced, drug therapy, physiopathology)
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