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Evaluation of dextromethorphan and carbetapentane as anticonvulsants and N-methyl-D-aspartic acid antagonists in mice.

Abstract
Two antitussives, dextromethorphan and carbetapentane, which have been reported to bind to a common binding site in brain tissue and produce anticonvulsant effects in rats, were evaluated for their anticonvulsant effects against maximal electroshock-induced seizures, for their neurological impairing effects on the horizontal screen test, and their protective effects against N-methyl-D-aspartic acid (NMDA)-induced lethality in mice. Both compounds protected animals against maximal electroshock-induced seizures in a dose-related fashion after either intraperitoneal or oral administration. The neurologically impairing doses were approximately 1.5 times the anticonvulsant doses. As a function of dose, dextromethorphan, but not carbetapentane, protected mice from NMDA-induced lethality. Since carbetapentane had an anticonvulsant action without protecting against NMDA-induced lethality, these data support the hypothesis that dextromethorphan and carbetapentane may have a common anticonvulsant action separate from the phencyclidine-like, NMDA-antagonist action which only dextromethorphan exhibits.
AuthorsJ D Leander
JournalEpilepsy research (Epilepsy Res) 1989 Jul-Aug Vol. 4 Issue 1 Pg. 28-33 ISSN: 0920-1211 [Print] Netherlands
PMID2666123 (Publication Type: Journal Article)
Chemical References
  • Anticonvulsants
  • Antitussive Agents
  • Cyclopentanes
  • Levorphanol
  • Aspartic Acid
  • carbetapentane
  • N-Methylaspartate
  • Dextromethorphan
Topics
  • Animals
  • Anticonvulsants (therapeutic use)
  • Antitussive Agents (therapeutic use)
  • Aspartic Acid (analogs & derivatives, antagonists & inhibitors, toxicity)
  • Cyclopentanes (therapeutic use)
  • Dextromethorphan (therapeutic use)
  • Dose-Response Relationship, Drug
  • Levorphanol (analogs & derivatives)
  • Male
  • Mice
  • N-Methylaspartate
  • Seizures (chemically induced, drug therapy, physiopathology)

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