Abstract | OBJECTIVE: To investigate the changes in lung injury and oxidative stress of sprague-Dawleyy (SD) rats at different times after single intratracheal instillation of potassium dichromate. METHODS: RESULTS: The rats in the potassium dichromate group had significantly decreased body weight on day 1 and day 3 after exposure than the control group (P<0.05). Lung coefficient increased significantly on day 7 (P<0.05) and kept increasing until the end of the experiment. The potassium dichromate group had a significantly higher activity of AKP than the control group on day 1 and day 7 after exposure (P<0.05). However, the potassium dichromate group had a significantly lower activity of GSH-Px than the control group on day 1 and day 3 after exposure (P<0.05). And the potassium dichromate group had a lower activity of reduced GSH than the control group on day 3 and day 7 after exposure. CONCLUSION: Single intratracheal instillation of 1.5 mg/kg potassium dichromate could result in lung inflammatory injury. of SD rats, and the injury is more severe on day 7 after exposure. Body injury is related to antioxidant activity, and the antioxidant.activity cannot recover completely on day 28 after exposure.
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Authors | Tianjing Wang, Yanshuang Song, Guang Jia |
Journal | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
(Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi)
Vol. 33
Issue 6
Pg. 414-6
(Jun 2015)
ISSN: 1001-9391 [Print] China |
PMID | 26653372
(Publication Type: Journal Article)
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Chemical References |
- Glutathione Peroxidase
- Alkaline Phosphatase
- Glutathione
- Potassium Dichromate
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Topics |
- Alkaline Phosphatase
(metabolism)
- Animals
- Bronchoalveolar Lavage Fluid
- Disease Models, Animal
- Glutathione
(blood)
- Glutathione Peroxidase
(metabolism)
- Lung
(physiopathology)
- Lung Injury
(chemically induced, physiopathology)
- Male
- Oxidative Stress
- Potassium Dichromate
(toxicity)
- Rats
- Rats, Sprague-Dawley
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