Abstract | OBJECTIVE: METHODS: From August 2010 to April 2013, we performed a case-control study in a Chinese Zhuang population, which included 1 024 CHD cases and 1 024 age and gender-matched non-CHD controls. The ABO blood groups and biological variables were measured by standard laboratory procedures. The Gensini score was used to evaluate the severity of coronary artery stenosis. RESULTS: Compared to non-CHD control group, CHD group had higher levels of fasting blood glucose ((6.71 ± 6.72) mmol/L vs. (4.98 ± 1.55) mmol/L, P < 0.001), LDL-C ((2.89 ± 1.18) mmol/L vs. (2.60 ± 1.05) mmol/L, P = 0.002) and CRP ((7.74 ± 7.32) mg/L vs. (2.93 ± 2.19)mg/L, P < 0.001) as well as higher proportion of history of hypertension (57.0% vs. 27.5%, P < 0.001), history of diabetes (29.6% vs. 9.6%, P < 0.001), family history of CHD (35.3% vs. 10.6%, P < 0.001) and smoking (51.0% vs. 38.2%, P < 0.001). Logistic analysis indicated that ABO blood groups were associated with CHD risk in the Chinese Zhuang population. Compared with group O, the group B individuals had a higher risk of CHD (OR = 2.33, 95% CI 1.88-2.90, P < 0.001), this result remained after adjustment for the conventional CHD risk factors (OR = 1.55, 95% CI 1.05-2.52, P = 0.047). In addition, there were significant differences of Gensini score between non-O subjects and group O subjects in the CHD group, and MACE at 1-year follow-up was similar between ABO blood groups of CHD individuals. CONCLUSION: ABO blood groups are associated with CHD risk in the Chinese Zhuang population.
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Authors | Ying Shi, Yingzhong Lin, Hairun Liu, Qingwei Ji, Zhihong Lu, Zhengde Lu, Nengwen Xu, Jun Yuan, Ling Liu |
Journal | Zhonghua xin xue guan bing za zhi
(Zhonghua Xin Xue Guan Bing Za Zhi)
Vol. 43
Issue 9
Pg. 788-92
(Sep 2015)
ISSN: 0253-3758 [Print] China |
PMID | 26652819
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- ABO Blood-Group System
- Asian People
- Case-Control Studies
- China
- Coronary Artery Disease
- Coronary Stenosis
- Diabetes Mellitus
- Humans
- Hypertension
- Smoking
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