HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Beta 2 microglobulin in some hematologic neoplasms].

Abstract
Beta 2 microglobulin is a low molecular weight protein integrating the light chain HLA antigens. Its serum concentration is increased in different neoplasias and in renal failure. Using solid phase RIA we determined the concentration of beta 2 microglobulin in plasma and spinal fluid of 57 healthy individuals and patients with hematologic neoplasia. Serum levels were 1.34 +/- 0.34 mg/l and spinal fluid levels were 1.3 +/- 0.7 mg/l in healthy subjects. Serum levels in 29 patients with myeloma was 7.51 mg/l, significantly higher in those with renal failure (12.35 mg/l) compared to those without (4.54). In 30 patients with non-Hodgkin lymphoma the mean serum levels were 2.90 mg/l, significantly greater in those with active disease (3.18) than in those with remission (1.5). No difference was found according to the degree of malignancy. Patients with acute lymphatic leukemia had elevated values of beta 2 microglobulin while the disease was active (3.37 mg/l), decreasing to normal levels after remission (1.79 mg/l). Spinal fluid levels of beta 2 microglobulin were elevated only in patients with central nervous system involvement. Our results indicate that serum levels of beta 2 microglobulin are helpful in patients with hematologic neoplasia in assessing the activity of the disease and tumor mass, especially in multiple myeloma.
AuthorsM A Rodríguez, P Lira, A Foradori, G Grebe
JournalRevista medica de Chile (Rev Med Chil) Vol. 116 Issue 6 Pg. 538-42 (Jun 1989) ISSN: 0034-9887 [Print] Chile
Vernacular TitleBeta 2 microglobulina en algunas neoplasias hematológicas.
PMID2664940 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • beta 2-Microglobulin
Topics
  • Adolescent
  • Adult
  • Aged
  • Blood Donors
  • Hodgkin Disease (analysis)
  • Humans
  • Middle Aged
  • Multiple Myeloma (analysis)
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma (cerebrospinal fluid)
  • Reference Values
  • beta 2-Microglobulin (analysis, cerebrospinal fluid)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: