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Electro-triggering and electrochemical monitoring of dopamine exocytosis from a single cell by using ultrathin electrodes based on Au nanowires.

Abstract
A sophisticated set of an Au nanowire (NW) stimulator-Au NW detector system is developed for electrical cell stimulation and electrochemical analysis of subsequent exocytosis with very high spatial resolution. Dopamine release from a rat pheochromocytoma cell is more stimulated by a more negative voltage pulse. This system could help to improve the therapeutic efficacy of electrotherapies by providing valuable information on their healing mechanism.
AuthorsMijeong Kang, Seung Min Yoo, Raekeun Gwak, Gayoung Eom, Jihwan Kim, Sang Yup Lee, Bongsoo Kim
JournalNanoscale (Nanoscale) Vol. 8 Issue 1 Pg. 214-8 (Jan 07 2016) ISSN: 2040-3372 [Electronic] England
PMID26645731 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Gold
  • Dopamine
Topics
  • Animals
  • Dopamine (metabolism)
  • Exocytosis (physiology)
  • Gold
  • Microelectrodes
  • Nanowires
  • PC12 Cells
  • Rats

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