[Clinical effectiveness of cefoperazone for respiratory infections of elderly patients, focusing on its safety on renal function].

Abstract

Clinical effectiveness of cefoperazone (CPZ) was studied for 46 elderly patients with respiratory infections. 1. Clinical efficacy rate of CPZ was 80.6% (29/36). 2. Adverse reactions occurred in 2 patients as systemic rush and fever. Laboratory abnormalities were observed in 5 patients. These included elevation of transaminase value. 3. The serum concentration of CPZ at 12 hours after administration of 2 g CPZ was not reflected in creatinine clearance and total bilirubin, and those 2 values appeared to have little effects on CPZ excretion. 4. The administration of CPZ at 4 g/day for less than 3 weeks had no effects on the renal function. As a result of this study, CPZ was found to have little undesirable effect on renal functions and to be a useful drug for the treatment of respiratory infections in elderly patients.

• Authors: H Tanimoto, T Suzuki, T Sato, Y Hirota, H Nagai, R Yoneda, Y Matsuda, K Morozumi, N Kohno, T Kuriyama
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 42 Issue 5 Pg. 1199-207 (May 1989) ISSN: 0368-2781 [Print] Japan
• PMID: 2664257 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Cefoperazone
• Creatinine
• Bilirubin

Topics

• Age Factors
• Aged
• Aged, 80 and over
• Bilirubin (blood)
• Cefoperazone (pharmacokinetics, pharmacology, therapeutic use)
• Clinical Trials as Topic
• Creatinine (blood)
• Female
• Humans
• Kidney (drug effects)
• Male
• Middle Aged
• Respiratory Tract Infections (drug therapy, physiopathology)