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A clinical and biochemical assessment of prinomide in patients with rheumatoid arthritis.

Abstract
Prinomide (CGS-10787B), a potential disease modifying drug, was evaluated clinically and biochemically in 15 patients with active rheumatoid arthritis. The single group study design included monthly assessments of 7 clinical measures and 22 laboratory measures. Twelve patients completed 24 weeks' therapy with prinomide 1.2 g/day. All clinical variables showed improvement which consistently reached statistical significance for articular index from Week 8 (p less than 0.01), for summated change score from Week 12 (p less than 0.01) and for pain score from Week 16 (p less than 0.05). Sustained significant improvement in laboratory variables was seen by Week 2 for erythrocyte sedimentation rate and platelet count (both p less than 0.05), and by Week 4 for plasma viscosity (p less than 0.01), IgG, IgA, IgM (all p less than 0.05).
AuthorsH A Bird, J Hill, J S Dixon, R Bojar, A Traficante, M A Catalano, S F Adair, L Liauw, H Sussman, H Rotman
JournalThe Journal of rheumatology (J Rheumatol) Vol. 16 Issue 4 Pg. 448-54 (Apr 1989) ISSN: 0315-162X [Print] CANADA
PMID2664168 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Pyrroles
  • prinomide
Topics
  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
  • Arthritis, Rheumatoid (drug therapy)
  • Clinical Trials as Topic
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pyrroles (therapeutic use)
  • Statistics as Topic

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