A clinical and biochemical assessment of prinomide in patients with rheumatoid arthritis.

Prinomide (CGS-10787B), a potential disease modifying drug, was evaluated clinically and biochemically in 15 patients with active rheumatoid arthritis. The single group study design included monthly assessments of 7 clinical measures and 22 laboratory measures. Twelve patients completed 24 weeks' therapy with prinomide 1.2 g/day. All clinical variables showed improvement which consistently reached statistical significance for articular index from Week 8 (p less than 0.01), for summated change score from Week 12 (p less than 0.01) and for pain score from Week 16 (p less than 0.05). Sustained significant improvement in laboratory variables was seen by Week 2 for erythrocyte sedimentation rate and platelet count (both p less than 0.05), and by Week 4 for plasma viscosity (p less than 0.01), IgG, IgA, IgM (all p less than 0.05).
AuthorsH A Bird, J Hill, J S Dixon, R Bojar, A Traficante, M A Catalano, S F Adair, L Liauw, H Sussman, H Rotman
JournalThe Journal of rheumatology (J Rheumatol) Vol. 16 Issue 4 Pg. 448-54 (Apr 1989) ISSN: 0315-162X [Print] CANADA
PMID2664168 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Pyrroles
  • prinomide
  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
  • Arthritis, Rheumatoid (drug therapy)
  • Clinical Trials as Topic
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pyrroles (therapeutic use)
  • Statistics as Topic

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: