The High Prevalence of Low HDL-Cholesterol Levels and Dyslipidemia in Rural Populations in Northwestern China.

Abstract

BACKGROUND:

Dyslipidemia is a major health problem in China and an important modifiable cardiovascular disease (CVD) risk factor. This study aimed to describe the prevalence of dyslipidemia and low high density lipoprotein cholesterol (HDL-cholesterol) and associated risk factors among adults in rural northwest China.

METHODS:

In a cross-sectional analyses involving 2,980 adults aged >18 years, information on the demographics, cigarette smoking, alcohol consumption, education, and medical history was collected via face-to-face interviews. Blood samples were collected to determine total cholesterol (TC), low-density lipoprotein cholesterol (LDL-cholesterol), and HDL-cholesterol, and triglycerides (TG) levels.

RESULTS:

The prevalence of high TC, high LDL-cholesterol, low HDL-cholesterol, and high TG were 1.0%, 0.6%, 60.9%, and 13.7%, respectively. TC, LDL-cholesterol, and TG increased with age in females. Elevated TC was more common in females than in males. The prevalence of low HDL-cholesterol was 67.6% in males and 55.4% in females. Current smokers, those with less education, those who were overweight or obese, and those with large waist circumference were more likely to have low HDL-cholesterol (p<0.05). Multivariable regression showed that male gender showed an association with low HDL-cholesterol (OR 2.10, 95%CI 1.68-2.61), age ≥60 years (OR 0.80, 95% CI 0.64-0.99), BMI (BMI = 24-27.9, OR 1.27, 95%CI 1.04-1.54, p = 0.02 and BMI≥28, OR 1.56, 95%CI 1.10-2.20, p = 0.01) and enlarged waist circumference (OR 2.10, 95%CI 1.51-2.92). Non-alcohol drinker was associated with low HDL-cholesterol levels (OR 0.72, 95%CI 0.53-0.99, p = 0.04).

CONCLUSIONS:

This study found that the prevalence of low HDL-cholesterol was 67.6% and 55.4% for males and females. Male gender, non-alcohol drinker, BMI and central obesity were important risk factors for low HDL-cholesterol in Chinese adults.

• Authors: Pengfei Ge, Caixia Dong, Xiaolan Ren, Elisabete Weiderpass, Chouji Zhang, Haoqiang Fan, Jing Zhang, Yongrui Zhang, Jinen Xi
• Journal: PloS one (PLoS One) Vol. 10 Issue 12 Pg. e0144104 ( 2015) ISSN: 1932-6203 [Electronic] United States
• PMID: 26640891 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholesterol, HDL
• Cholesterol, LDL
• Triglycerides

Topics

• Adult
• Alcohol Drinking (epidemiology)
• Blood Pressure
• Body Mass Index
• Cardiovascular Diseases (epidemiology)
• China (epidemiology)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Cross-Sectional Studies
• Dyslipidemias (blood, epidemiology)
• Female
• Humans
• Male
• Middle Aged
• Obesity (epidemiology)
• Risk Factors
• Rural Population
• Sex Factors
• Smoking (epidemiology)
• Surveys and Questionnaires
• Triglycerides (blood)
• Young Adult