Antimicrobial and antioxidant screening of N¢-substituted sulphonyl and benzoyl derivatives of 4-Pyridine carboxylic acid hydrazide.

Abstract

In this research program, the antibacterial, antifungal and antioxidant activities of six N'-substituted sulfonyl and benzoyl derivatives of lead molecule PCH were reported. Out of these compounds, sulphonyl derivatives 2,3 and benzoyl derivative 5 showed moderate to good activity against different strains of gram-positive and gram-negative bacteria including B. cereus, B. subtilis, B. thruingiensis and S. pyogenes, S. fecalis and E. coli ATCC 8739. Moreover, upon antifungal screening, the compound, N¢-[(2,4,6-trimethylbenzene) sulfonyl]pyridine-4-carbohydrazide possessed good antifungal activity against Candida species, a causative agent of systemic fungal infections. Antioxidant study demonstrated more than 50% inhibition in DPPH assay for sulphonyl derivative 2 indicating its potential as antioxidant while the other derivatives expressed low level of radical scavenging property.

• Authors: Sabahat Naeem, Shamim Akhtar, Nadia Asghar, Sikander Khan Sherwani, Nousheen Mushtaq, Arfa Kamil, Shaista Zafar, Mohammad Arif, Zafar Saeed Saify
• Journal: Pakistan journal of pharmaceutical sciences (Pak J Pharm Sci) Vol. 28 Issue 6 Pg. 2129-34 (Nov 2015) ISSN: 1011-601X [Print] Pakistan
• PMID: 26639506 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Antifungal Agents
• Antioxidants
• Biphenyl Compounds
• Carboxylic Acids
• Hydrazines
• Picrates
• Pyridines
• 1,1-diphenyl-2-picrylhydrazyl

Topics

• Anti-Bacterial Agents (chemical synthesis, pharmacology)
• Antifungal Agents (chemical synthesis, pharmacology)
• Antioxidants (chemical synthesis, pharmacology)
• Bacteria (drug effects, growth & development)
• Biphenyl Compounds (chemistry)
• Candida (drug effects, growth & development)
• Carboxylic Acids (chemical synthesis, pharmacology)
• Hydrazines (chemical synthesis, pharmacology)
• Microbial Sensitivity Tests
• Molecular Structure
• Picrates (chemistry)
• Pyridines (chemical synthesis, pharmacology)
• Structure-Activity Relationship