Effective treatment of cytomegalovirus retinitis and neuritis with retrobulbar ganciclovir after treosulfan-based autologous bone marrow transplant.

Abstract	We describe the case of a 16-month-old girl with neuroblastoma and chronic lymphocytopenia due to chemotherapy and treosulfan-containing megatherapy who developed cytomegalovirus retinitis and neuritis. Intravenous ganciclovir and anti-cytomegalovirus immunoglobulin were used with a transient benefit; however, retrobulbar gancyclovir resulted in a complete remission. This report emphasizes the need for close monitoring of viral infections in patients undergoing treosulfan-containing megatherapy, highlighting the immunosuppressive effects of this agent, and indicates the potential use of retrobulbar ganciclovir as the alternative method of drug delivery.
Authors	Anna Raciborska, Marek Ussowicz, Marek Prost, Katarzyna Bilska, Carlos Rodriguez-Galindo, Magdalena Rychlowska-Pruszynska
Journal	Klinika oczna (Klin Oczna) Vol. 117 Issue 2 Pg. 101-3 ( 2015) ISSN: 0023-2157 [Print] Poland
PMID	26638547 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antineoplastic Agents, Alkylating Antiviral Agents treosulfan Busulfan Ganciclovir
Topics	Antineoplastic Agents, Alkylating (adverse effects) Antiviral Agents (administration & dosage) Bone Marrow Transplantation (adverse effects) Busulfan (adverse effects, analogs & derivatives) Cytomegalovirus Infections (drug therapy, etiology) Female Ganciclovir (administration & dosage) Humans Infant Leukemia (complications, therapy) Retinitis (drug therapy, etiology) Treatment Outcome

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