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Leukemogenic Activity of Cohesin Rings True.

Abstract
Cohesin complex components are frequently mutated in human myeloid cancers. Three new studies now show that cohesin mutations disrupt the differentiation of normal hematopoietic stem and progenitor cells and enhance self-renewal, shedding light on how these alterations may contribute to leukemic transformation.
AuthorsMark S Williams, Tim C P Somervaille
JournalCell stem cell (Cell Stem Cell) Vol. 17 Issue 6 Pg. 642-644 (12 03 2015) ISSN: 1875-9777 [Electronic] United States
PMID26637939 (Publication Type: Journal Article, Comment)
CopyrightCopyright © 2015 Elsevier Inc. All rights reserved.
Topics
  • Cell Differentiation
  • Hematologic Neoplasms
  • Hematopoietic Stem Cells (cytology)
  • Humans
  • Mutation
  • Myeloproliferative Disorders

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