Abstract | OBJECTIVE: MATERIALS AND METHODS: Literatures published before May 2015 were searched in PubMed and EMBASE. The data were retrieved and the sensitivity, specificity, positive/negative likelihood ratio (PLR/NLR), diagnostic odds ratio (DOR) of adenosine deaminase for diagnosing tuberculous pericarditis were pooled, and the summary receiver operating characteristic (SROC) curves were used to examine the overall performance of adenosine deaminase. RESULTS: In total, 11 studies with 938 subjects were included in the meta-analysis. The summary estimates of adenosine deaminase for diagnosing tuberculous pericarditis were listed as follows: sensitivity of 0.90 (95% CI: 0.86-0.93), specificity of 0.86 (95% CI: 0.83-0.89), PLR of 5.90 (95% CI: 4.46-7.82), NLR of 0.15 (95% CI: 0.09-0.26), and DOR of 42.55 (95% CI: 21.51-84.18). The area under the SROC curve was 0.92, and the Q value was 0.85. No publication bias was identified. CONCLUSIONS:
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Authors | D L Xie, B Cheng, Y Sheng, J Jin |
Journal | European review for medical and pharmacological sciences
(Eur Rev Med Pharmacol Sci)
Vol. 19
Issue 22
Pg. 4411-8
(Nov 2015)
ISSN: 2284-0729 [Electronic] Italy |
PMID | 26636531
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- Biomarkers
- Adenosine Deaminase
|
Topics |
- Adenosine Deaminase
(blood)
- Biomarkers
(blood)
- Humans
- Pericarditis, Tuberculous
(blood, diagnosis)
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