Abstract |
A highly convergent, stereocontrolled total synthesis of the architecturally complex marine sponge metabolite (-)- enigmazole A has been achieved. Highlights include an unprecedented late-stage large-fragment Petasis-Ferrier union/rearrangement, a multicomponent Type I Anion Relay Chemistry ( ARC) tactic, and a dithiane- epoxide union in conjunction with an oxazole-directed stereoselective reduction.
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Authors | Yanran Ai, Mariya V Kozytska, Yike Zou, Anton S Khartulyari, Amos B Smith 3rd |
Journal | Journal of the American Chemical Society
(J Am Chem Soc)
Vol. 137
Issue 49
Pg. 15426-9
(Dec 16 2015)
ISSN: 1520-5126 [Electronic] United States |
PMID | 26632969
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Macrolides
- Organophosphorus Compounds
- Oxazoles
- enigmazole A
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Topics |
- Macrolides
(chemical synthesis, chemistry)
- Molecular Structure
- Organophosphorus Compounds
(chemical synthesis, chemistry)
- Oxazoles
(chemical synthesis, chemistry)
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