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[Each one case of Vogt-Koyanagi-Harada disease with vestibular and cerebellar ataxia, and multiple cranial nerve palsies].

Abstract
Two cases of Vogt-Koyanagi-Harada disease with rare neurological complications were reported, which are one case with vestibular and cerebellar ataxia, and one with multiple cranial nerve palsies. The first case, a 32-year-old man, was admitted to our ophthalmologic department because of visual impairment. Two weeks later, he complained of gait disturbance. Limb and truncal ataxia, vestibular dysfunction and perceptive deafness were observed. Ophthalmologic examination revealed typical findings of Vogt-Koyanagi-Harada disease. CSF showed elevated protein and mononuclear pleocytosis. After treatment with oral steroid therapy, vestibular and cerebellar ataxia, and visual impairment improved. The second case, a 22-years-old man, showed the VIIth, VIIIth, IXth, and Xth cranial nerve palsies with visual impairment, and he was diagnosed to have cranial nerve palsies associated with Vogt-Koyanagi-Harada disease. After steroid therapy, there was a marked clinical improvement. Vogt-Koyanagi-Harada disease is an autoimmune disease against the melanocytes and involving tissues containing melanocytes such as uvea, meningea, skin and inner ear, etc.. Neurological complications except for meningitis and perceptive deafness have been rarely reported in Japan. Related to the present cases, possible pathogenesis was discussed.
AuthorsY Hiraki, N Kuwasaki, H Shoji, M Kaji, T Kuboshiro
JournalRinsho shinkeigaku = Clinical neurology (Rinsho Shinkeigaku) Vol. 29 Issue 1 Pg. 54-8 (Jan 1989) ISSN: 0009-918X [Print] Japan
PMID2663296 (Publication Type: Case Reports, English Abstract, Journal Article, Review)
Chemical References
  • Betamethasone
  • Prednisolone
Topics
  • Adult
  • Ataxia (drug therapy, etiology)
  • Betamethasone (administration & dosage)
  • Cerebellar Ataxia (drug therapy, etiology)
  • Cranial Nerve Diseases (drug therapy, etiology)
  • Humans
  • Labyrinth Diseases (drug therapy, etiology)
  • Male
  • Prednisolone (administration & dosage)
  • Uveitis (complications)
  • Uveomeningoencephalitic Syndrome (complications, drug therapy)
  • Vestibule, Labyrinth

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