[Hypotensive and hemodynamic effects of guanfacine in arterial hypertension].

Abstract

The therapeutic efficacy of guanfacine was investigated in a group of 32 hypertensive patients. Guanfacine caused a marked decrease in total peripheral vascular resistance (by 19.8%, p less than 0.001) and, hence, in blood pressure (by 19.4%), p less than 0.001). A slight reduction in the heart rate (by 9.8%, p less than 0.01) was compensated by an increase in stroke volume (by 11.8%, p less than 0.05) so that cardiac output remained constant or was even slightly raised. After 4 weeks of treatment there was a regression of the left ventricular wall thickness and mass (by 7.43 +/- 2.44 g, p less than 0.05). Guanfacine monotherapy was effective in 75% of patients with moderate hypertension (using low doses 1-3 mg/day). In severe hypertensive disease a satisfactory therapeutic response was mostly achieved by a combination of Guanfacine (3-5 mg/day) with a beta-blocker, diuretic or vasodilator. Guanfacine is a promising agent in the long-term treatment of stable hypertension, particularly in patients, whom diuretics or beta-blockers are contraindicated.

• Authors: E V Erina, E V Beliakova, Kh Z Charyev, V V Panfilov
• Journal: Biulleten' Vsesoiuznogo kardiologicheskogo nauchnogo tsentra AMN SSSR (Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR) Vol. 12 Issue 1 Pg. 63-7 ( 1989) ISSN: 0201-7369 [Print] Russia (Federation)
• Vernacular Title: Gipotenzivnyĭ i gemodinamicheskie effekty guanfatsina pri arterial'noĭ gipertonii.
• PMID: 2663029 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antihypertensive Agents
• Guanidines
• Phenylacetates
• Guanfacine

Topics

• Adult
• Aged
• Antihypertensive Agents (therapeutic use)
• Guanfacine
• Guanidines (therapeutic use)
• Hemodynamics (drug effects)
• Humans
• Hypertension (drug therapy, physiopathology)
• Middle Aged
• Myocardial Contraction (drug effects)
• Phenylacetates (therapeutic use)