Abstract | BACKGROUND: AIMS: METHODS: 23 and 22 patients with AISC and PSC, respectively, underwent review of colonoscopy and biopsy findings, capsule enteroscopy and assessment of clinical and inflammatory (faecal calprotectin) disease activity, which was compared with that of patients with ulcerative colitis and Crohn's disease (n = 55 each). FINDINGS: Five and 6 patients with AISC and PSC, respectively, had normal colonoscopy and faecal calprotectin levels of 34.4 ± 8.3 and 39.7 ± 8.4 μg/g, respectively (normal < 50 μg/g), whereas 18 and 16, respectively, had identical variably severe, right sided colitis with frequent rectal sparing, consistent with ulcerative colitis. Mean (± SD) faecal calprotectin levels did not differ significantly (p > 0.05) between patients with intestinal inflammation in AISC (588 ± 549 μg/g), PSC (421 ± 351 μg/g), ulcerative colitis (501 ± 656 μg/g) or Crohn's disease (476 ± 571 μg/g). Capsule enteroscopy showed that 7 of 18 (39%) (p < 0.03) of those with AISC had small bowel mucosal breaks whereas no patient with PSC had these findings. INTERPRETATION:
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Authors | Ingvar Bjarnason, Bu Hayee, Polychronis Pavlidis, Charlotte Kvasnovsky, Astrid Scalori, Guy Sisson, Annika Charlesworth, Hizbullah Shaikh, Einar Bjornsson, Michael A Heneghan |
Journal | EBioMedicine
(EBioMedicine)
Vol. 2
Issue 10
Pg. 1523-7
(Oct 2015)
ISSN: 2352-3964 [Electronic] Netherlands |
PMID | 26629548
(Publication Type: Journal Article)
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Chemical References |
- Leukocyte L1 Antigen Complex
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Topics |
- Adolescent
- Adult
- Biopsy
- Child
- Cholangitis, Sclerosing
(complications, diagnosis, drug therapy)
- Colitis, Ulcerative
(complications, diagnosis)
- Colonoscopy
- Crohn Disease
(complications, diagnosis)
- Female
- Humans
- Inflammatory Bowel Diseases
(complications, diagnosis, drug therapy)
- Intestinal Mucosa
(pathology)
- Leukocyte L1 Antigen Complex
- Male
- Middle Aged
- Young Adult
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