[Chemotherapy of bacteroides infection under clinical and experimental conditions].

Abstract

Bacteroides were detected in pus and bioptates of the majority of 125 patients with purulent and purulent septic infections of various localization. In 90 per cent of the subjects the bacteroides were detected in association with aerobes, facultative and obligate anaerobic bacteria. The species of the bacteroides and concomitant microflora isolated from the cases with different diseases were defined by endogenic sources of the microbial contamination. Sensitivity of 112 bacteroide strains to antimicrobial agents was tested. Chloramphenicol, clindamycin, metronidazole, cefotaxime and heliomycin proved to be the most efficient. Efficacy of heliomycin was detected in hamsters with experimental bacteroide infection in the buccal sac. Thorough bacteriological examination is required for rational chemotherapy of bacteroide infections.

• Authors: L G Miasnikova, M S Poliak
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 34 Issue 5 Pg. 386-90 (May 1989) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Khimioterapiia bakteroidnykh infektsiĭ v klinike i eksperimente.
• PMID: 2662930 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Culture Media

Topics

• Animals
• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Bacteroides Infections (drug therapy)
• Bacteroides fragilis (drug effects)
• Clinical Trials as Topic
• Cricetinae
• Culture Media
• Drug Evaluation, Preclinical
• Drug Resistance, Microbial
• Humans
• In Vitro Techniques