Abstract | BACKGROUND AND PURPOSE: METHODS: RESULTS: CONCLUSIONS: These results support the idea that lipid raft integrity, ensured by seladin-1/DHCR24, plays a crucial protective role in the ischemic brain by guaranteeing EAAT2-mediated uptake of glutamate excess.
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Authors | Macarena Hernández-Jiménez, Diego Martínez-López, Enrique Gabandé-Rodríguez, Adrian Martín-Segura, Ignacio Lizasoain, María D Ledesma, Carlos G Dotti, María A Moro |
Journal | Stroke
(Stroke)
Vol. 47
Issue 1
Pg. 206-13
(Jan 2016)
ISSN: 1524-4628 [Electronic] United States |
PMID | 26628388
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 American Heart Association, Inc. |
Chemical References |
- Androstenes
- Excitatory Amino Acid Transporter 2
- Nerve Tissue Proteins
- Slc1a2 protein, mouse
- 3-beta-(2-(diethylamino)ethoxy)androst-5-en-17-one
- Glutamic Acid
- Oxidoreductases Acting on CH-CH Group Donors
- Dhcr24 protein, mouse
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Topics |
- Androstenes
(pharmacology)
- Animals
- Animals, Newborn
- Cells, Cultured
- Excitatory Amino Acid Transporter 2
(genetics, metabolism)
- Glutamic Acid
(metabolism)
- Male
- Membrane Microdomains
(drug effects, genetics, metabolism)
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Nerve Tissue Proteins
(antagonists & inhibitors, deficiency, genetics)
- Oxidoreductases Acting on CH-CH Group Donors
(antagonists & inhibitors, deficiency, genetics)
- Stroke
(genetics, metabolism, prevention & control)
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