Abstract | CONTEXT: OBJECTIVE: To describe the potential use of disulfiram in treating acetonitrile poisoning in a human clinical case and to further study its effect in human liver microsomes in vitro. CASE DETAILS: RESULTS: DISCUSSION: Although disulfiram was given late in the course of the poisoning it is possible that it contributed to the recovery.
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Authors | Peter De Paepe, Pieter Colin, Pieter Depuydt, An-Sofie Decavele, Julie De Smet, Koen Boussery, Christophe Stove, Dominique Benoit, Alain Verstraete, Jan Van Bocxlaer, Walter Buylaert |
Journal | Clinical toxicology (Philadelphia, Pa.)
(Clin Toxicol (Phila))
Vol. 54
Issue 1
Pg. 56-60
( 2016)
ISSN: 1556-9519 [Electronic] England |
PMID | 26623950
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Acetonitriles
- Biomarkers
- Blood Alcohol Content
- Cholinesterase Inhibitors
- Cyanides
- Ethanol
- Aldicarb
- Disulfiram
- acetonitrile
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Topics |
- Acetonitriles
(blood, poisoning)
- Acidosis, Lactic
(blood, chemically induced, diagnosis, drug therapy)
- Adult
- Alcohol Drinking
(adverse effects, blood)
- Aldicarb
(blood, poisoning)
- Biomarkers
(blood)
- Blood Alcohol Content
- Cholinesterase Inhibitors
(blood, poisoning)
- Cyanides
(blood)
- Disulfiram
(therapeutic use)
- Ethanol
(adverse effects, blood)
- Humans
- Male
- Microsomes, Liver
(drug effects, metabolism)
- Poisoning
(blood, diagnosis, drug therapy)
- Time Factors
- Treatment Outcome
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