Abstract | BACKGROUND: METHODS: RESULTS: The overall response rate was 42.2%, with 1 patient (2.2%) showing complete remission, 18 patients (40.0%) with partial remission, 19 (42.2%) with stable disease (SD), and 7 (15.6%) with progressive disease, respectively. The most common hematological toxicity was leucopenia with grade 0, I, II, III and IV in 16 (35.6%), 10 (22.2%), 11 (24.4%), 7 (15.6%), and 1 patient (2.2%), respectively. Thirty-seven patients (82.2%) experienced grade I-II nausea/ vomiting without grade III-IV instances occurring. Four patients (8.9%) experienced grade I hepatotoxicity. No nephrotoxicity was observed. Five in thirteen patients treated with concurrent chemoradiotherapy (CRT) suffered severe radiation pneumonitis. The dysphagia resolved or improved in 32 patients (71%). CONCLUSIONS:
Lobaplatin- paclitaxel showed a significant antitumor effect to squamous esophageal cancer with manageable toxicities. Limitation of the surveillance time and the retrospective nature, the effect that based on these data formal prospective trials appear warranted and are needed prior to routine first line use of this regimen.
|
Authors | Ming-Qiu Chen, Cheng Chen, Hai-Jie Lu, Ben-Hua Xu |
Journal | Journal of thoracic disease
(J Thorac Dis)
Vol. 7
Issue 10
Pg. 1749-55
(Oct 2015)
ISSN: 2072-1439 [Print] China |
PMID | 26623097
(Publication Type: Journal Article)
|