Abstract | BACKGROUND: CASE REPORT: A male patient with the chief complaints of headache, gross hematuria, and nocturia was referred to our hospital. Based on renal biopsy, the diagnosis was finally confirmed as anti-GBM disease combined with IgA nephropathy and, the patient received comprehensive treatment, including cyclophosphamide (CTX), which led to symptom improvement. Two days after the third impulse CTX was given, he suddenly experienced headache and dizziness, which eventually developed into a tonic-clonic seizure. RPLS was identified by cranial magnetic resonance imaging (MRI) with reversible neuroimaging. After diazepam and antihypertension management, seizures were controlled. RPLS, a neurological complication, was found in anti-GBM disease with IgA nephropathy during our immunosuppressants therapy for the first time. CONCLUSIONS:
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Authors | Ya-ting Ge, Jin-lan Liao, Wei Liang, Zu-ying Xiong |
Journal | The American journal of case reports
(Am J Case Rep)
Vol. 16
Pg. 849-53
(Dec 01 2015)
ISSN: 1941-5923 [Electronic] United States |
PMID | 26621456
(Publication Type: Case Reports, Journal Article)
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Topics |
- Anti-Glomerular Basement Membrane Disease
(complications, diagnosis)
- Biopsy
- Brain
(pathology)
- Diagnosis, Differential
- Glomerulonephritis, IGA
(complications, diagnosis)
- Humans
- Kidney
(pathology)
- Magnetic Resonance Imaging
- Male
- Posterior Leukoencephalopathy Syndrome
(diagnosis, etiology)
- Young Adult
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