Abstract |
A Chemiluminescent System (CLS), using a Peroxyoxalate chemiluminescent solution (PCs), together with Hematoporphyrin derivative (HpD) Photofrin II., were utilized in the treatment of transplanted mammary adenocarcinomas in C3H/HeJ female mice. Tumor bearing animals aged 2-4 months were divided into five groups; Group I was the control. Groups 2 and 4 compared the effectiveness of both reagents HpD and PCs which were administered by intratumor injections fractionated over a 96 hour period. Groups 3 and 5 compared the effectiveness of PCs alone. Tests of the PCs were conducted with and without the presence of luminescence. Fifty-three percent of the animals in Group 4 and 47% of the animals in Group 2 remained tumor free 120 days after the completion of treatment. Thirty percent of the animals in Groups 2 and 4 survived one year without tumor recurrence. The results of this study suggest that a chemical light system can be a viable alternative in Photodynamic Therapy ( PDT) to laser light for the activation of HpD and treatment of cancer.
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Authors | M J Phillip, P P Maximuke |
Journal | Oncology
(Oncology)
Vol. 46
Issue 4
Pg. 266-72
( 1989)
ISSN: 0030-2414 [Print] Switzerland |
PMID | 2662091
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Topics |
- Adenocarcinoma
(drug therapy)
- Animals
- Female
- Hematoporphyrin Photoradiation
(methods)
- Luminescent Measurements
- Mammary Neoplasms, Experimental
(drug therapy)
- Mice
- Mice, Inbred C3H
- Photochemotherapy
(methods)
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