Genetic association of the ApoB and ApoA1 gene polymorphisms with the risk for alcohol-induced osteonecrosis of femoral head.

Abstract

Polymorphisms of apolipoprotein B (ApoB), apolipoprotein A1 (ApoA1) gene and ApoB/ApoA1 Ratio were associated with lipid metabolism disorders in previous reports. The aim of this study assess whether variation of ApoB, ApoA1 gene are associated or not with alcohol-induced osteonecrosis of femoral head (ONFH). In a case-control study, we genotyped 4 single-nucleotide polymorphisms (SNPs) in ApoB and ApoA1 genes in 209 alcohol-induced ONFH patients and 300 healthy control subjects in Han Chinese population using χ(2) test and genetic model analysis. The analysis revealed that the frequencies of ApoB and ApoA1 genotypes were significantly different in alcohol-induced ONFH patients than in controls. We identified rs1042034, rs676210 and rs673548 in ApoB gene were associated with decreased risk of alcohol-induced ONFH using recessive model analysis (odds ratio [OR], 0.44; 95% confidence interval [CI], 0.19-0.99; P = 0.042), the OR, CI, P value of three SNPs were the same after adjusted for gender + age. We also identified rs632153 in ApoA1 gene was associated with increased risk of alcohol-induced ONFH using allele model (OR, 1.83; 95% CI, 1.16-2.88; P = 0.008) and log-additive model (adjusted OR, 1.77; 95% CI, 1.00-3.14; P = 0.046), analysis respectively. Haplotype analysis demonstrated no difference between ApoB and alcohol-induced ONFH. Polymorphisms of the ApoB and ApoA1 gene are associated with alcohol-induced ONFH in the Han Chinese population.

• Authors: Yuan Wang, Yuju Cao, Yizhou Li, Yongchang Guo, Quanjian Wang, Min Yang, Ning Zhang, Tianbo Jin, Jianzhong Wang
• Journal: International journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 8 Issue 9 Pg. 11332-9 ( 2015) ISSN: 1936-2625 [Electronic] United States
• PMID: 26617857 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• APOA1 protein, human
• APOB protein, human
• Apolipoprotein A-I
• Apolipoprotein B-100
• Genetic Markers

Topics

• Alcohol Drinking (adverse effects, ethnology)
• Apolipoprotein A-I (genetics)
• Apolipoprotein B-100 (genetics)
• Asian People (genetics)
• Case-Control Studies
• Chi-Square Distribution
• China (epidemiology)
• Femur Head Necrosis (diagnosis, ethnology, genetics)
• Gene Frequency
• Genetic Association Studies
• Genetic Markers
• Genetic Predisposition to Disease
• Haplotypes
• Humans
• Linkage Disequilibrium
• Logistic Models
• Odds Ratio
• Phenotype
• Polymorphism, Single Nucleotide
• Risk Assessment
• Risk Factors