Metastatic and prognostic factors in patients with alveolar echinococcosis.

Abstract

BACKGROUND:

Prognostic predictions in alveolar echinococcosis (AE) are usually based on relapse and metastasis. Thus, assessment of factors associated with metastasis and clinical outcomes in patients with alveolar echinococcosis are of significant important. The purpose of this study was to investigate the correlated factors for metastasis and prognosis for patients with AE.

METHODS:

We analyzed 159 AE patients who underwent curative surgery at the First Teaching Hospital of Xinjiang Medical University from February 2003 to December 2013 by hematoxylin and eosin (HE) staining. Immunohistochemistry (IHC) staining for CD44 was performed in 159 AE and adjacent normal liver specimens. The clinicopathological parameters were analyzed for metastasis and prognosis, including gender, age, size, calcification, necrosis, foreign body granuloma and CD44 protein level.

RESULTS:

The rate of metastasis was 22.1%. Chi-square test showed that low levels of CD44 was associated with metastasis (P = 0.004). However, multivariate analysis suggested that CD44 expression is not independent prognostic indicators for overall survival (P = 0.356). In addition, no correlations between prognosis and gender, age, size, calcification, necrosis, foreign body granulomatous, metastasis were identified.

CONCLUSIONS:

The finding that a low level of CD44 is associated with metastasis in AE patients. At present, it thus remains question whether CD44 expression is a valid prognostic marker for AE, further investigations are required.

• Authors: Hui Wang, Chang Lu, Xia Liu, Wei Zhang
• Journal: International journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 8 Issue 9 Pg. 11192-8 ( 2015) ISSN: 1936-2625 [Electronic] United States
• PMID: 26617841 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• CD44 protein, human
• Hyaluronan Receptors

Topics

• Adolescent
• Adult
• Aged
• Biomarkers (analysis)
• Biopsy
• Disease Progression
• Down-Regulation
• Echinococcosis
• Echinococcosis, Hepatic (immunology, parasitology, pathology, surgery)
• Female
• Humans
• Hyaluronan Receptors (analysis)
• Immunohistochemistry
• Lung (immunology, parasitology, pathology, surgery)
• Male
• Middle Aged
• Pneumonectomy
• Predictive Value of Tests
• Retrospective Studies
• Risk Factors
• Treatment Outcome
• Young Adult