Propylparaben-induced disruption of energy metabolism in human HepG2 cell line leads to increased synthesis of superoxide anions and apoptosis.

Abstract

The effect of propylparaben (in final concentrations 0.4 ng/ml, 2.3 ng/ml and 4.6 ng/ml) on the energy metabolism of HepG2 hepatocytes, superoxide anion synthesis, apoptosis and necrosis is described. Propylparaben can be toxic to liver cells due to the increased production of superoxide anions, which can contribute to a reduced concentration of superoxide dismutase in vivo and impairment of the body's antioxidant mechanisms. Finally, a further reduction in the mitochondrial membrane potential and uncoupling of the respiratory chain resulting in a reduction in ATP concentration as a result of mitochondrial damage may lead to cell death by apoptosis.

• Authors: S Szeląg, A Zabłocka, K Trzeciak, A Drozd, I Baranowska-Bosiacka, A Kolasa, M Goschorska, D Chlubek, I Gutowska
• Journal: Toxicology in vitro : an international journal published in association with BIBRA (Toxicol In Vitro) Vol. 31 Pg. 30-4 (Mar 2016) ISSN: 1879-3177 [Electronic] England
• PMID: 26616278 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 Elsevier B.V. All rights reserved.

Chemical References

• Adenine Nucleotides
• Parabens
• Superoxides
• Adenosine Triphosphate
• propylparaben

Topics

• Adenine Nucleotides (metabolism)
• Adenosine Triphosphate (metabolism)
• Apoptosis (drug effects)
• Energy Metabolism (drug effects)
• Hep G2 Cells
• Humans
• Membrane Potential, Mitochondrial (drug effects)
• Mitochondria, Liver (drug effects)
• Necrosis (chemically induced)
• Parabens (pharmacology)
• Superoxides (metabolism)