Adiponectin gene polymorphisms are associated with increased susceptibility to diabetic peripheral neuropathy.

Abstract

BACKGROUND:

Adiponectin (ADP) polymorphisms associated with diabetes mellitus in several populations. However, no previous studies have investigated its association with diabetic peripheral neuropathy (DPN). Our study examined the association between ADP-linked SNPs and DPN susceptibility.

METHODS:

We randomly recruited 160 diabetes mellitus (DM) patients and 80 healthy individuals.

RESULTS:

The C allele of rs3821799 increased DPN susceptibility. In normal individuals, GG of rs3774261 carriers had 7.1 times higher DPN susceptibility than AA carriers. The haplotype analyzes indicated CGG might increase DPN susceptibility.

CONCLUSION:

Our study demonstrated that ADP gene polymorphisms are associated with the susceptibility to DPN.

• Authors: Yao Chen, Jian Wang, Lijing Wang, Peiji Huang, Zeng-Xian Tan, Huai-Jun Liu
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 20 Issue 6-7 Pg. 474-80 ( 2015) ISSN: 1366-5804 [Electronic] England
• PMID: 26616148 (Publication Type: Journal Article)

Chemical References

• ADIPOQ protein, human
• Adiponectin
• Blood Glucose
• Glycated Hemoglobin A
• Lipoproteins, LDL
• Thyroglobulin
• Cholesterol

Topics

• Adiponectin (genetics)
• Alleles
• Base Sequence
• Blood Glucose (metabolism)
• Cholesterol (blood)
• Diabetic Neuropathies (blood, genetics)
• Female
• Gene Frequency
• Genetic Predisposition to Disease (genetics)
• Genotype
• Glycated Hemoglobin (metabolism)
• Haplotypes
• Humans
• Linkage Disequilibrium
• Lipoproteins, LDL (blood)
• Male
• Middle Aged
• Odds Ratio
• Polymorphism, Single Nucleotide
• Sequence Analysis, DNA (methods)
• Thyroglobulin (blood)