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Beyond multidrug-resistant tuberculosis in Europe: a TBNET study.

Abstract
The emergence of drug-resistant tuberculosis (TB) is a challenge to TB control in Europe. We evaluated second-line drug susceptibility testing in Mycobacterium tuberculosis isolates from patients with multidrug-resistant, pre-extensively drug-resistant (pre-XDR-TB) and XDR-TB at 23 TBNET sites in 16 European countries. Over 30% of bacilli from patients with pre-XDR-TB showed resistance to any fluoroquinolone and almost 70% to any second-line injectable drug. Respectively >90% and >80% of the XDR-TB strains tested showed phenotypic resistance to pyrazinamide and ethambutol. Resistance to prothionamide/ethionamide was high in bacilli from pre-XDR-TB patients (43%) and XDR-TB patients (49%).
AuthorsG Günther, F van Leth, N Altet, M Dedicoat, R Duarte, G Gualano, H Kunst, I Muylle, V Spinu, S Tiberi, P Viiklepp, C Lange, TBNET
JournalThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease (Int J Tuberc Lung Dis) Vol. 19 Issue 12 Pg. 1524-7 (Dec 2015) ISSN: 1815-7920 [Electronic] France
PMID26614196 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Chemical References
  • Antitubercular Agents
  • Fluoroquinolones
  • Pyrazinamide
  • Ethambutol
  • Ethionamide
Topics
  • Adult
  • Antitubercular Agents (therapeutic use)
  • Ethambutol (therapeutic use)
  • Ethionamide (therapeutic use)
  • Europe
  • Extensively Drug-Resistant Tuberculosis (drug therapy)
  • Female
  • Fluoroquinolones (therapeutic use)
  • Humans
  • Logistic Models
  • Male
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis (drug effects)
  • Pyrazinamide (therapeutic use)

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