Reduction of increased serum neutrophil chemotactic activity following effective hyposensitization in house dust mite allergy.

Abstract

Changes in the level of serum neutrophil chemotactic activity (S-NCA) were investigated in 20 subjects with allergic rhinitis, with or without asthma, undergoing clinically effective hyposensitization to house dust mite with Pharmalgen Dermatophagoides pteronyssinus. Two control groups were studied: 28 subjects with allergic rhinitis, with or without asthma, receiving placebo injections for 1 yr in a double-blind controlled trial with Pharmalgen D. pteronyssinus (from whom the actively treated group in this study were recruited), and eight non-atopic asymptomatic controls. S-NCA and serum IgE specific to D. pteronyssinus were measured in the subjects before, during (3-6 months) and 12 months after treatment, and once in the non-atopic controls. The mean S-NCA was significantly higher (0.01 greater than P greater than 0.001) in subjects before treatment (mean +/- s.e. = 63.8 +/- 3.6 arbitrary units of migration (AUM] compared with the non-atopic controls (48.5 +/- 3.7 AUM), but had fallen to normal levels after 6 months (46.8 +/- 4.0 AUM) and 12 months treatment (45.2 +/- 3.8 AUM). The levels of S-NCA in the placebo treated group were significantly higher than normal at the start of treatment (69.2 +/- 4.1) and remained raised throughout the 12 months treatment. In the actively treated group, the level of S-NCA had fallen in 18 out of 19 subjects after 12 months immunotherapy, and was unaltered in one. Mean levels of D. pteronyssinus IgE rose during the first 6 months and declined to initial levels by the end of the treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: S M McHugh, P W Ewan
• Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (Clin Exp Allergy) Vol. 19 Issue 3 Pg. 327-34 (May 1989) ISSN: 0954-7894 [Print] England
• PMID: 2660970 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Chemotactic Factors
• Dust
• Interleukin-8
• Immunoglobulin E

Topics

• Adult
• Animals
• Chemotactic Factors (analysis)
• Desensitization, Immunologic
• Double-Blind Method
• Dust
• Female
• Humans
• Immunoglobulin E (analysis)
• Immunotherapy
• Injections
• Interleukin-8
• Male
• Mites (immunology)
• Rhinitis, Allergic, Perennial (blood, therapy)
• Time Factors