Abstract | INTRODUCTION: METHODS: RESULTS: In separate analyses of the three cohorts, the incidence rate of CV events was higher in patients with the rs734553 risk (T) allele (TT/GT) than in those without (GG patients) and the HR in TT/GT patients in the three cohorts (range 1.72-2.14) coherently signaled an excessive cardiovascular risk with no heterogeneity (I2 = 0.01). The meta-analytical estimate (total number of patients, n = 1227; total CV events, n = 222) of the HR for the combined end-point in TT/GT patients was twice higher (pooled HR: 2.04, 95% CI: 1.11-3.75, P = 0.02) than in GG homozygotes. CONCLUSIONS: The T allele of the rs734553 polymorphism in the GLUT9 gene predicts a doubling in the risk for incident cardiovascular events in patients at high cardiovascular risk. Findings in this study are compatible with the hypothesis of a causal role of hyperuricemia in cardiovascular disease in high risk conditions.
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Authors | A Testa, S Prudente, D Leonardis, B Spoto, M C Sanguedolce, R M Parlongo, G Tripepi, S Rizza, F Mallamaci, M Federici, V Trischitta, C Zoccali |
Journal | Nutrition, metabolism, and cardiovascular diseases : NMCD
(Nutr Metab Cardiovasc Dis)
Vol. 25
Issue 12
Pg. 1087-94
(Dec 2015)
ISSN: 1590-3729 [Electronic] Netherlands |
PMID | 26607700
(Publication Type: Comparative Study, Journal Article, Meta-Analysis, Review)
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Copyright | Copyright © 2015 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Genetic Markers
- Glucose Transport Proteins, Facilitative
- SLC2A9 protein, human
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Topics |
- Aged
- Cardiovascular Diseases
(epidemiology, genetics, physiopathology)
- Cause of Death
- Cohort Studies
- Comorbidity
- Female
- Genetic Markers
(genetics)
- Glucose Transport Proteins, Facilitative
(genetics)
- Humans
- Hyperuricemia
(epidemiology, genetics, physiopathology)
- Incidence
- Male
- Middle Aged
- Polymorphism, Genetic
- Predictive Value of Tests
- Risk Assessment
- Survival Analysis
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