Abstract |
Using patients with carcinomatous peritonitis caused by gastric cancer, we conducted a Phase II clinical study of LC 9018 by administering the agent alone or in combination with mitomycin C (MMC). Out of 29 patients enrolled, 12 were treated with LC 9018 alone and 17 others with LC 9018 + MMC. Of these, 15 cases were found completely evaluable. The response rate for 15 complete cases against carcinomatous peritonitis was 60.0% (3/5) for the group treated with LC9018 alone and 70.0% (7/10) with LC9018 + MMC. Of the 27 eligible patients, the ascites could be controlled in 58.3% (7/12) for those treated with LC9018 alone and 60.0% (9/15) for those with LC9018 + MMC, with tumor cells being eliminated in 50.0% (6/12) and 60.0% (9/15), respectively. Major adverse reactions included fever, nausea/ vomiting, abdominal pain and increases in GOT and GPT. These findings suggest that LC9018 might be a useful therapeutic agent against carcinomatous peritonitis of gastric cancer whether used alone or in combination with MMC.
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Authors | T Okamura, Y Maehara, K Sugimachi |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 16
Issue 6
Pg. 2257-62
(Jun 1989)
ISSN: 0385-0684 [Print] Japan |
PMID | 2660750
(Publication Type: Case Reports, Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article, Multicenter Study)
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Chemical References |
- Adjuvants, Immunologic
- LC 9018
- Mitomycins
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Topics |
- Adjuvants, Immunologic
(adverse effects, therapeutic use)
- Adult
- Aged
- Ascites
(pathology, therapy)
- Combined Modality Therapy
- Drug Evaluation
- Female
- Fever
(etiology)
- Humans
- Japan
- Lacticaseibacillus casei
- Male
- Middle Aged
- Mitomycins
(therapeutic use)
- Multicenter Studies as Topic
- Peritonitis
(etiology, therapy)
- Remission Induction
- Stomach Neoplasms
(complications, pathology)
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