[A Long-Term Survival Case of Unresectable Hilar Bile Duct Cancer Treated with Gemcitabine].

Abstract

A 69-year-old woman was diagnosed with liver dysfunction on blood testing in a nearby clinic. Computed tomography revealed stenosis of the hilar bile duct. Accordingly, an endoscopic nasobiliary drainage tube was inserted in the left hepatic duct and she was referred to our hospital for diagnostic examinations and treatment. The endoscopic retrograde cholangiopancreatography findings revealed obstruction of the cystic duct and stenosis of the hilar bile duct due to inflammation of the cystic duct or inflammation of the clamping type by cholecystitis. Considering the possibility of malignant tumor, surgical operation was performed. Radical resection was considered impossible and we instead performed cholecystectomy and resection of a bile duct wall specimen for diagnosis. The pathological diagnosis was poorly differentiated tubular adenocarcinoma. The patient was treated with gemcitabine as systemic chemotherapy for unresectable hilar bile duct cancer. Currently, 78 months after the start of chemotherapy, the patient is alive and well, without tumor progression.

• Authors: Hiroshi Furukawa, Kensuke Kumamoto, Yasuhide Kofunato, Rei Yashima, Tatsuo Shimura, Yoshihisa Koyama, Seiichi Takenoshita
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 42 Issue 11 Pg. 1439-41 (Nov 2015) ISSN: 0385-0684 [Print] Japan
• PMID: 26602408 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Deoxycytidine
• Gemcitabine

Topics

• Adenocarcinoma (drug therapy, surgery)
• Aged
• Antimetabolites, Antineoplastic (therapeutic use)
• Bile Duct Neoplasms (drug therapy, pathology, surgery)
• Cholangiopancreatography, Endoscopic Retrograde
• Cholecystectomy
• Combined Modality Therapy
• Deoxycytidine (analogs & derivatives, therapeutic use)
• Female
• Humans
• Time Factors
• Treatment Outcome
• Gemcitabine