Abstract | BACKGROUND: MATERIALS AND METHODS: Forty consequently CVST patients from two University Hospital in Isfahan University of Medical Sciences aged more than 15 years from January 2009 to January 2011 were recruited. In parallel, 51 healthy subjects with the same age and race from similar population selected as controls. FV Leiden, FII GA20210, MTHFR C677T, and FV Cambridge gene mutations by polymerase chain reaction technique were evaluated in case and control groups. RESULTS:
FV Leiden, FII GA20210, and FV Cambridge gene mutations had very low prevalence in both case (5%, 2%, 0%) and control (2.5%, 0%, 0%) and were not found any significant difference between groups. MTHFR C677T mutations was in 22 (55%) of patients in case group and 18 (35.5%) of control group (P = 0.09). CONCLUSION: This study showed that the prevalence of FV Leiden, FII GA20210, and FV Cambridge were low. Laboratory investigations of these mutations as a routine test for all patients with CVST may not be cost benefit.
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Authors | Mohammad Saadatnia, Mansour Salehi, Ahmad Movahedian, Seyed Ziaeddin Samsam Shariat, Mehri Salari, Marzieh Tajmirriahi, Elham Asadimobarakeh, Rasoul Salehi, Gilda Amini, Homa Ebrahimi, Ehsan Kheradmand |
Journal | Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
(J Res Med Sci)
Vol. 20
Issue 6
Pg. 554-62
(Jun 2015)
ISSN: 1735-1995 [Print] India |
PMID | 26600830
(Publication Type: Journal Article)
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