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Five Simultaneous Primary Tumors in a Single Patient: A Case Report and Review of the Literature.

Abstract
Multiple primary malignancies (MPMs) are present when a patient is diagnosed with more than one primary malignancy and when each tumor is histologically unrelated to the others. MPMs are considered synchronous when they present within 6 months of one another. Here, we report the case of a 57-year-old woman with a past medical history significant for melanoma in 1988, who presented in 2014 with 5 distinct tumors within 4 months: malignant melanoma of the right popliteal fossa, invasive lobular breast carcinoma, diffuse large B cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, and a giant cell tumor of tendon sheath/pigmented villonodular synovitis. We discuss her treatment and also present a brief review of the literature. The incidence of MPMs appears to be on the rise, which demands an interdisciplinary, multimodal, and personalized approach to care.
AuthorsCasey W Williamson, Anthony Paravati, Majid Ghassemi, Kristine Lethert, Patricia Hua, Patricia Hartman, Parag Sanghvi
JournalCase reports in oncology (Case Rep Oncol) 2015 Sep-Dec Vol. 8 Issue 3 Pg. 432-8 ISSN: 1662-6575 [Electronic] Switzerland
PMID26600775 (Publication Type: Journal Article)

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