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Impact of common SNPs in VEGF gene on the susceptibility of osteosarcoma.

Abstract
We conducted a case-control study to assess the role of vascular endothelial growth factor (VEGF) -634G/C, +936C/T, and +1612G/A genetic variations in the development of osteosarcoma in a Chinese population. This hospital-based case-control study examined 130 patients with osteosarcoma and 130 age- and gender-matched healthy controls from March 2011 and March 2013. Polymerase chain reaction-restriction fragment length polymorphism was applied to assess the VEGF -634G/C, +936C/T, and +1612G/A gene polymorphisms. Using conditional regression analysis, individuals carrying the TT genotype of VEGF +936C/T were found to be correlated with an elevated risk of osteosarcoma, with an adjusted odds ratio (95% confidence interval) of 2.70 (1.02-8.28). In conclusion, our study suggests that the TT genotype of VEGF +936C/T genetic variants is associated with an increased risk of osteosarcoma.
AuthorsG L Hu, G Ma, J H Ming
JournalGenetics and molecular research : GMR (Genet Mol Res) Vol. 14 Issue 4 Pg. 14561-6 (Nov 19 2015) ISSN: 1676-5680 [Electronic] Brazil
PMID26600515 (Publication Type: Journal Article)
Chemical References
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
Topics
  • Adult
  • Asian People
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Osteosarcoma (genetics, pathology)
  • Risk Factors
  • Vascular Endothelial Growth Factor A (genetics)

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