Abstract |
We conducted a case-control study to assess the role of vascular endothelial growth factor ( VEGF) -634G/C, +936C/T, and +1612G/A genetic variations in the development of osteosarcoma in a Chinese population. This hospital-based case-control study examined 130 patients with osteosarcoma and 130 age- and gender-matched healthy controls from March 2011 and March 2013. Polymerase chain reaction-restriction fragment length polymorphism was applied to assess the VEGF -634G/C, +936C/T, and +1612G/A gene polymorphisms. Using conditional regression analysis, individuals carrying the TT genotype of VEGF +936C/T were found to be correlated with an elevated risk of osteosarcoma, with an adjusted odds ratio (95% confidence interval) of 2.70 (1.02-8.28). In conclusion, our study suggests that the TT genotype of VEGF +936C/T genetic variants is associated with an increased risk of osteosarcoma.
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Authors | G L Hu, G Ma, J H Ming |
Journal | Genetics and molecular research : GMR
(Genet Mol Res)
Vol. 14
Issue 4
Pg. 14561-6
(Nov 19 2015)
ISSN: 1676-5680 [Electronic] Brazil |
PMID | 26600515
(Publication Type: Journal Article)
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Chemical References |
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
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Topics |
- Adult
- Asian People
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genotype
- Humans
- Male
- Middle Aged
- Osteosarcoma
(genetics, pathology)
- Risk Factors
- Vascular Endothelial Growth Factor A
(genetics)
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