Quantitative assessment of the association between the angiotensin-converting enzyme gene insertion/deletion polymorphism and digestive system cancer risk.

Abstract	The angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism has been reported to be associated with digestive system cancer; however, the results from previous studies have been conflicting. The present study aimed to investigate the association between the ACE I/D polymorphism and the risk of digestive system cancer using a meta-analysis of previously published studies. Databases were systematically searched to identify relevant studies published prior to December 2014. We estimated the pooled OR with its 95%CI to assess the association. The meta-analysis consisted of thirteen case-control studies that included 2557 patients and 4356 healthy controls. Meta-analysis results based on all the studies showed no significant association between the ACE I/D polymorphism and the risk of digestive system cancer (DD vs II: OR = 0.85, 95%CI = 0.59-1.24; DI vs II: OR = 0.94, 95%CI = 0.78-1.15; dominant model: OR = 0.96, 95%CI = 0.81- 1.15; recessive model: OR = 1.06, 95%CI = 0.76-1.48). Subgroup analyses by race and cancer type did not detect an association between the ACE I/D polymorphism and digestive system cancer risk. However, when the analyses were restricted to smaller studies (N < 500 patients), the summary OR of DI vs II was 0.80 (95%CI = 0.66-0.97). Our analyses detected a possibility of publication bias with a misestimate of the true association by smaller studies. Overall, meta-analysis results suggest the ACE I/D polymorphism might not be associated with susceptibility to digestive system cancer. Further large and well-designed studies are needed to confirm these conclusions.
Authors	J Wang, S Yang, F H Guo, X Mao, H Zhou, Y Q Dong, Z M Wang, F Luo
Journal	Genetics and molecular research : GMR (Genet Mol Res) Vol. 14 Issue 4 Pg. 14291-9 (Nov 13 2015) ISSN: 1676-5680 [Electronic] Brazil
PMID	26600487 (Publication Type: Journal Article, Meta-Analysis)
Chemical References	Peptidyl-Dipeptidase A
Topics	Case-Control Studies Digestive System Neoplasms (enzymology, genetics) Genetic Association Studies Genetic Predisposition to Disease Humans INDEL Mutation Peptidyl-Dipeptidase A (genetics) Polymorphism, Genetic Publication Bias Risk Factors

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