Abstract |
Auto- antibodies assist with the diagnosis of ocular paraneoplastic syndromes and autoimmune ocular conditions; however, the frequency of positive test results as a possible precursor to future disease is unknown. The frequency of positive antibodies in heavy smokers who may be at risk for autoimmune-related retinopathy and optic neuropathy was evaluated. Serum antibody activity was evaluated through the use of Western blot reactions from pig retina and optic nerve extract. Fifty-one patients were included: 35 patients were smokers (average: 40.9 pack-year history) and 26 patients had no past smoking history. None of the patients had any visual complaints or known eye disease. Of the patients studied, 76.5% (39 patients: 18 smokers, 21 non-smokers) had positive antiretinal antibodies, and 19.6% (10 patients: 3 smokers, 7 non-smokers) had positive antioptic nerve antibodies. Anti- retinal antibodies were seen in a majority of randomly selected patients with and without a past smoking history. Anti-optic nerve bodies were less common, but more prevalent in those who never smoked. The specificity of these antibodies remains greatly uncertain and clinical correlation is warranted.
|
Authors | Eric K Chin, David R P Almeida, Khoa V Lam, John L Keltner, Charles E Thirkill |
Journal | Ophthalmic surgery, lasers & imaging retina
(Ophthalmic Surg Lasers Imaging Retina)
2015 Nov-Dec
Vol. 46
Issue 10
Pg. 1068-70
ISSN: 2325-8179 [Electronic] United States |
PMID | 26599255
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright 2015, SLACK Incorporated. |
Chemical References |
- Autoantibodies
- Autoantigens
- Eye Proteins
|
Topics |
- Animals
- Autoantibodies
(blood)
- Autoantigens
(immunology)
- Blotting, Western
- Eye Proteins
(immunology)
- Healthy Volunteers
- Humans
- Optic Nerve
(immunology)
- Optic Nerve Diseases
(immunology)
- Paraneoplastic Syndromes, Ocular
(immunology)
- Retina
(immunology)
- Retinal Diseases
(immunology)
- Smoking
(immunology)
- Swine
|