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Positive Auto-Antibody Activity With Retina and Optic Nerve in Smokers and Non-Smokers: The Controversy Continues.

Abstract
Auto-antibodies assist with the diagnosis of ocular paraneoplastic syndromes and autoimmune ocular conditions; however, the frequency of positive test results as a possible precursor to future disease is unknown. The frequency of positive antibodies in heavy smokers who may be at risk for autoimmune-related retinopathy and optic neuropathy was evaluated. Serum antibody activity was evaluated through the use of Western blot reactions from pig retina and optic nerve extract. Fifty-one patients were included: 35 patients were smokers (average: 40.9 pack-year history) and 26 patients had no past smoking history. None of the patients had any visual complaints or known eye disease. Of the patients studied, 76.5% (39 patients: 18 smokers, 21 non-smokers) had positive antiretinal antibodies, and 19.6% (10 patients: 3 smokers, 7 non-smokers) had positive antioptic nerve antibodies. Anti-retinal antibodies were seen in a majority of randomly selected patients with and without a past smoking history. Anti-optic nerve bodies were less common, but more prevalent in those who never smoked. The specificity of these antibodies remains greatly uncertain and clinical correlation is warranted.
AuthorsEric K Chin, David R P Almeida, Khoa V Lam, John L Keltner, Charles E Thirkill
JournalOphthalmic surgery, lasers & imaging retina (Ophthalmic Surg Lasers Imaging Retina) 2015 Nov-Dec Vol. 46 Issue 10 Pg. 1068-70 ISSN: 2325-8179 [Electronic] United States
PMID26599255 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2015, SLACK Incorporated.
Chemical References
  • Autoantibodies
  • Autoantigens
  • Eye Proteins
Topics
  • Animals
  • Autoantibodies (blood)
  • Autoantigens (immunology)
  • Blotting, Western
  • Eye Proteins (immunology)
  • Healthy Volunteers
  • Humans
  • Optic Nerve (immunology)
  • Optic Nerve Diseases (immunology)
  • Paraneoplastic Syndromes, Ocular (immunology)
  • Retina (immunology)
  • Retinal Diseases (immunology)
  • Smoking (immunology)
  • Swine

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