[Clinical evaluation of M-VAC chemotherapy (methotrexate, vinblastine, adriamycin and cisplatin) for advanced urothelial cancer].

Abstract

Combination chemotherapy with methotrexate, vinblastine, adriamycin and cisplatin (M-VAC regimen) was administered to 12 patients with advanced epithelial cancer of the urinary tract in a clinical trial undertaken to assess clinical efficacy of this multiagent therapy. This series comprised 11 males and 1 female ranging in age from 46 to 76 years (mean age: 63), with performance status (PS) being rated 0 in 2, 1 in 5, 2 in 2, 3 in 2 and 4 in 1 of these 12 patients. The site of primary lesion was bladder in 8, renal pelvis in 3 and ureter in 1. Histologically, these tumors were all identified as transitional cell carcinoma (grade 3) with the exception of 1 mixed type (transitional cell carcinoma plus squamous carcinoma). Nine of the patients had already their primary tumor resected surgically while the remaining 3 had undergone only biopsy. The site of metastasis was lung in 7, bone in 4 and lymph nodes in 3. In consideration of the patients' general condition, the dosages of the chemotherapeutic agents were set at 80% of those recommended by Sternberg. Of the 9 patients with primary tumor resected, 1 died of chemotherapy; of the remaining 9 patients, the M-VAC regimen brought about CR in 1 and PR in 4, hence with a response rate of 62.5%. The 4 patients showing PR underwent surgical resection of residual tumor and 2 of them achieved CR and have been free of a recurrence during a 33- or 29-month period of the chemotherapeutic regimen.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: K Gohji, A Takenaka, A Goto, I Hara, O Matsumoto, S Kamidono, G Hamami, A Itani, K Harada, N Tadera
• Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology (Nihon Hinyokika Gakkai Zasshi) Vol. 80 Issue 3 Pg. 321-8 (Mar 1989) ISSN: 0021-5287 [Print] Japan
• PMID: 2659869 (Publication Type: Case Reports, Clinical Trial, English Abstract, Journal Article)

Chemical References

• Vinblastine
• Doxorubicin
• Cisplatin
• Methotrexate

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Carcinoma, Squamous Cell (drug therapy, surgery)
• Carcinoma, Transitional Cell (drug therapy, surgery)
• Cisplatin (administration & dosage, adverse effects)
• Clinical Trials as Topic
• Combined Modality Therapy
• Doxorubicin (administration & dosage, adverse effects)
• Female
• Humans
• Male
• Methotrexate (administration & dosage, adverse effects)
• Middle Aged
• Urologic Neoplasms (drug therapy, surgery)
• Vinblastine (administration & dosage, adverse effects)