Association between interleukin-22 genetic polymorphisms and bladder cancer risk.

Abstract

OBJECTIVE:

The cytokine interleukin-22 (IL-22), which is produced by T cells and natural killer cells, is associated with tumorigenesis and tumor progression in cancers. However, the role of IL-22 in bladder cancer has not been investigated.

MATERIALS AND METHODS:

A prospective hospital-based case-control study comprising 210 patients with pathologically proven bladder cancer and 210 age- and gender-matched healthy controls was conducted. The genotypes of 3 common polymorphisms (-429 C/T, +1046 T/A and +1995 A/C) of the IL-22 gene were determined with fluorogenic 5' exonuclease assays.

RESULTS:

Patients with bladder cancer had a significantly higher frequency of the IL-22 -429 TT genotype [odds ratio (OR)=2.04, 95% confidence interval (CI)=1.19, 3.49; p=0.009] and -429 T allele (OR=1.42, 95% CI=1.08, 1.87; p=0.01) than the healthy controls. These findings were still significant after a Bonferroni correction. When stratifying according to the stage of bladder cancer, we found that patients with superficial bladder cancer had a significantly lower frequency of the IL-22 -429 TT genotype (OR=0.48, 95% CI=0.23, 0.98; p=0.04). When stratifying according to the grade and histological type of bladder cancer, we found no statistical association. The IL-22 +1046 T/A and IL-22 +1995 A/C gene polymorphisms were not associated with the risk of bladder cancer.

CONCLUSION:

To the authors' knowledge, this is the first report documenting that the IL-22 -429 C/T gene polymorphism is associated with bladder cancer risk. Additional studies are required to confirm this finding.

• Authors: Tao Zhao, XiaoHou Wu, JiaJi Liu
• Journal: Clinics (Sao Paulo, Brazil) (Clinics (Sao Paulo)) Vol. 70 Issue 10 Pg. 686-90 (Oct 2015) ISSN: 1980-5322 [Electronic] United States
• PMID: 26598081 (Publication Type: Journal Article)

Chemical References

• Interleukins
• interleukin-22

Topics

• Aged
• Carcinoma, Papillary (genetics)
• Case-Control Studies
• Female
• Gene Frequency
• Genetic Association Studies
• Genetic Predisposition to Disease
• Genotype
• Humans
• Interleukins (classification, genetics)
• Male
• Middle Aged
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Prospective Studies
• Risk Factors
• Urinary Bladder Neoplasms (genetics)