Abstract | BACKGROUND: METHODS AND MATERIALS: RESULTS: Thirteen patients were enrolled. Two patients discontinued cetuximab due to hypersensitivity reaction. The median age was 65 years (range 46-70), nine were females, and 85% had stage IIIB disease. Dose-limiting toxicity events (diarrheoa, febrile neutropenia and thrombocytopenia) occurred in 3 of 11 patients. The most common grade 3-4 side-effects were radiation dermatitis (63%), haematologic toxicity (54%), and diarrheoa (36%). No treatment-related deaths occurred. Three months following completion of treatment, ten patients (91%) had a local complete remission (CR), but two patients had developed liver metastases, yielding a total CR rate of 73%. CONCLUSION: The MTDs were determined as 5FU 800 mg/m(2) on RT days 1-4 and 29-32 and MMC 8 mg/m(2) on days 1 and 29 when combined with IMRT/VMAT with SIB and cetuximab in locally advanced anal cancer.
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Authors | Otilia Leon, Marianne G Guren, Calin Radu, Adalsteinn Gunnlaugsson, Anders Johnsson |
Journal | European journal of cancer (Oxford, England : 1990)
(Eur J Cancer)
Vol. 51
Issue 18
Pg. 2740-6
(Dec 2015)
ISSN: 1879-0852 [Electronic] England |
PMID | 26597443
(Publication Type: Clinical Trial, Phase I, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Ltd. All rights reserved. |
Chemical References |
- Mitomycin
- Cetuximab
- Fluorouracil
|
Topics |
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Anus Neoplasms
(pathology, therapy)
- Carcinoma, Squamous Cell
(secondary, therapy)
- Cetuximab
(adverse effects, therapeutic use)
- Chemoradiotherapy
(adverse effects)
- Disease Progression
- Disease-Free Survival
- Female
- Fluorouracil
(adverse effects, therapeutic use)
- Humans
- Kaplan-Meier Estimate
- Liver Neoplasms
(secondary)
- Male
- Maximum Tolerated Dose
- Middle Aged
- Mitomycin
(adverse effects, therapeutic use)
- Neoplasm Staging
- Norway
- Prospective Studies
- Radiotherapy, Intensity-Modulated
(adverse effects)
- Remission Induction
- Sweden
- Time Factors
- Treatment Outcome
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